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cigarette using tobacco will lessen the level or outcome of caffeine by influencing hepatic enzyme CYP1A2 metabolism. Minimal/Significance Not known.Because CYP3A4 inhibition elevates ergotamine and caffeine serum amounts, the risk for vasospasm resulting in cerebral ischemia and/or ischemia from the extremities is enhancedDEA's a few-issue Investi

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